Agarwood leaf

機能性表示食品
～便秘気味の方の便通を改善する～

Born from an industry-government-academia joint project

Only one functional food material with patent income

ginkgo leaves

(Patent No. 5187802 Laxative and food containing the same)

便通改善時の副作用が極めて少ない弊社独自原料。

In addition to improving bowel movements, detox effect and

The effect of improving the intestinal environment has also been confirmed.

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What is Jinkou?

A very rare tree called "God's Tree", cultivated without pesticides for more than 8 years.

■ Thymelaeaceae Plants belonging to the genus Daphne
Scientific name: Aquilaria subintegra
■ Production areas: tropical and subtropical countries such as Thailand, Vietnam, and Cambodia
■ The agar wood of the wood partThe king of fragrant trees "Kami no Ki"It is called such as fragrant wood and resin.
The resulting fragrance oil is distributed at a high price. (It is also used in herbal medicine.)
■ History: Agarwood is recorded in the Nihonshoki.Named by Prince Shotoku.
■ Food experience of jinkou leaves: In Southeast Asia such as Thailand,“Agarwood leaves improve bowel movements.
do goodThere is a traditional saying that

INFORMATION

Basic information

Ginkgo leaf extract powder (Food material with functional claims)

Name: Ginkgo leaf extract powder
Origin: Jinkouha
Effectiveness: bowel movement improvement (Compatible with functional labeling), improvement of intestinal environment, detox
Functional Ingredients: Genquanin 5-O-β-primeveroside, Mangiferin
Properties: powder (light brown to brown)
Recommended daily intake: 300 mg to 600 mg, 600 mg as a food with function claims
Compatible dosage forms: tablets, hard capsules, soft capsules, granules, drinks, jelly, etc.

Development history

Creative Seeds Development Business Success Certification（scienceJapan Technology Agency BulletinNo. 868)
Commercialization of seeds owned by Gifu Pharmaceutical University
In 2007 (Heisei 19), it was adopted as a 'JST Creative Seeds Deployment Business Consignment Development', and an industry-government-academia collaborative development project started.
After 4 years of research, he succeeded in developing a functional food that relieves constipation.
It was judged that there was a prospect of satisfying the technical requirements of "obtaining labeling permission for food for specified health use", which is the criteria for success or failure.

Carefully cultivated and harvested at reliable contracted farms

The country of origin is Thailand, the "Land of Smiles"
I actually went to the site and visited the farm. The raw materials we handle are safe and secure raw materials cultivated and harvested from pesticide-free farms that we can trust.

EFFECTS

Effect/Efficacy

Three major effects: improvement of intestinal environment, improvement of bowel movement, and detoxification!

On gingko leaves,Improvement of intestinal environment, bowel movements, detoxeffect is recognized.
As a result of a clinical trial targeting constipation-prone adult men and women, in two reports that met the eligibility criteria, the amount of defecation, the number of defecations, and the number of defecation days significantly increased, and the quality (hardness) of stools significantly improved. A bowel movement improvement effect was recognized.
In addition, it has been suggested that jinkou leaves may reduce intestinal putrefactive substances (indole) and improve the intestinal environment. It was also confirmed that there was no

A new material that improves bowel movements without strong side effectsis.
While laxatives directly stimulate the large intestine, ginkgo biloba works on acetylcholine receptors and stimulates the small intestine to promote peristalsis, so side effects seen in laxatives (irritant) are extremely rare. can be taken continuously.

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EVIDENCE

evidence

～Functionality～

Non-clinical studies

Improvement of constipation and promotion of defecation

-Action on drug-induced constipation model mice-

～Comparison of drugs in constipation model mice～

A constipation improvement effect was observed in drug (loperamide hydrochloride)-induced constipation model mice.

In Senna, the symptoms of diarrhea (a lot of water and the shape of the stool was broken) were confirmed.

Human clinical trial

Improvement of constipation and promotion of defecation

～600mg/day～

Continuous intake of ginko leaf extract powder (600 mg/day) for 2 weeks showed statistically significant results in the items of defecation frequency, defecation volume, and defecation days.

~Defecation days in a week~

Food containing 600 mg of gingko leaf extract powder or food containing no gingko leaf extract powder was ingested for 4 weeks. A significant difference was confirmed in comparison with the control food.

~Safety~

Non-clinical studies

■ Reverse mutation test (Ames test)

■ Chromosome aberration test

■ Micronucleus test

■ Single dose toxicity test

Repeated dose toxicity test (28 days)

Human clinical trial

■ Safety confirmation test for abdominal symptoms by single ingestion
(Subjects: 10 men)
(Test method: Open test)

■ Safety confirmation test for adult men and women by long-term intake
(22 males and females aged 20 to under 65)
(Test method: Open test)

■ Safety confirmation test for adult men and women due to overdose
(22 males and females aged 20 to under 65)
(Test method: Open test)

1）Biosci.Biotechnol.Biochem., 74(8), 1550-1555, 2010

2）Jpn Pharmacol Ther（薬理と治療） 2017, vol.45 no.1

3）坂井ら, Jpn Pharmacol Ther（薬理と治療） 2017, vol.45 no.1 113-120, 表4より作図

FUNCTIONAL FOOD