Royal Jelly Peptide

機能性表示食品
～肌の潤い（水分）を逃しにくくする～

gift from bees

Original food ingredients with functional claims that trace the history of API

royal jelly peptide

(Acceptance of food with functional claims: acceptance number E609)

In addition to the three major nutrients, protein, carbohydrate, and lipid,

Contains well-balanced vitamins and minerals

It is an effective material for beauty and health.

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*You can request a tasting sample from the inquiry form.

What is royal jelly?

``Royal Jelly'' is one of the three pillars that have supported API's trust and performance for over 100 years.

Many people seem to confuse it with honey, but honey is mostly made of sugar,

What is royal jelly peptide (RJ peptide)?

Proteolytic enzyme for raw royal jelly(Protease N: manufactured by Amano Enzyme)

It is a peptide material obtained by processing.

We focused on the functionality of raw royal jelly, which has such an effect, for "moisturizing the skin".,

About 30 years of researchRoyal Jelly Peptide was developed by repeating the above.

Basic information

Royal jelly peptide (food material with functional claims)

Name: Royal jelly peptide
Origin: Royal jelly
Efficacy: antihypertensive action, antioxidant action,Moisturizes the skin (Compliant with functional claims)
Functional component: royal jelly-derived peptide
Color tone: white
Recommended daily intake: 1000 mg or more as a food with function claims
Compatible dosage forms: tablets, hard capsules, soft capsules, granules, drinks, jelly, etc.

abundant nutrients

The worker bees decompose and synthesize the pollen and nectar they collect from flowers, and the cream-like substance secreted from the mandibular line and hypopharyngeal glands is a highlynutritious special food given to the queen bee.
The queen bee has many characteristics that differ from those of worker bees. It is 2 to 3 times longer, has a life span of 30 to 40 times longer, and continues to lay about 1,500 eggs every day. It is royal jelly that supports this vitality.
It has been used as a medicine and health food overseas for a long time, and in Japan it is widely used for purposes such as nutritional tonic and measures against menopausal symptoms.

History from ancient times

Royal jelly was mentioned about 2,400 years ago in the "Animal History" written by the historical figure philosopher Aristotle. Also known as the world's three most beautiful women, ancient EgyptianCleopatra also used it for beauty.It is said that.
Research began in various parts of Europe in the 1900s, and in 1954, with the permission of the French Ministry of Health, it began to be prescribed as a medicine. It has been recognized since it was clinically reported.
In Japan in 1959, an article published in a weekly magazine revealed that the general publicNew medicine for longevitybegan to be imported as a candidate for

Effect/Efficacy

Increased absorbency and solubility + skin moisturizing power + lower blood pressure

Royal jelly peptides are made by enzymatically decomposing and processing the proteins in raw royal jelly. 10-hydroxy-2-decenoic acid, which is an index component of royal jelly, and other nutrients,Increased absorption and solubility, and evenskin moisturizing powerhas also been found to be effective.
again,hypotensionThe effect of bringing about is also confirmed,Suitable for those with high blood pressureFood for Specified Health Uses “Stay Balance RJ”It is also used as an ingredient involved in

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evidence

～Functionality～

Human clinical trial (skin)

Pharmacology and Treatment 2018;46(8):1417-24

For women aged 30 to 60 who are concerned about dry skin,

Placebo foods or foods containing yar jelly peptide 2 times a day, 2 tablets/ 4 tablets/day (1000mg/day of royal jelly peptide)

We conducted a continuous intake test for 8 weeks each.

Change in transepidermal water loss of the skin (cheek)

It was confirmed that the water content of the royal jelly peptide-containing food group (1000 mg/day intake) was significantly improved compared to the placebo food group.

Skin cell proliferation ability

(In-house report)

The quantitative evaluation of the proliferative ability of royal jelly peptide on normal human skin fibroblasts was confirmed. (Positive control FGF)

Royal jelly peptide significantly enhanced the proliferation of normal human dermal fibroblasts in a dose-dependent manner.

Decenoic acid

• 10-Hydroxy-2-decenoic acid (decenoic acid) is an index component of royal jelly and is also contained in royal jelly peptides.

• It has been confirmed that it promotes collagen production by normal human dermal fibroblasts (NHDF cells), and produces TGF-β1 which is involved in collagen production. ¹⁾

• In culture cell tests, 10-hydroxy-2-decenoic acid suppresses cell damage caused by UV radiation. ²⁾

antioxidant effect

(In-house report)

-Several antioxidant peptides have been isolated and purified from the enzyme-treated product of royal jelly obtained by a method equivalent to royal jelly peptide, and reported. ³⁾

-Dry royal jelly (FD-RJ) before enzymatic degradation, and antioxidant peptide content in enzymatically degraded "royal jelly peptide"

The antioxidant peptide is produced only by enzymatic decomposition.

Human clinical trial (decreased blood pressure)

The Japan Society of Health Sciences. 21(2):229-245(2005).

Targeting normal hypertension and I-degree hypertension

Placebo or stay balance RJ (royal jelly peptide 1200mg/piece x 2 pieces/day)

A continuous intake test was conducted for 12 weeks each.

Staybalance RJ showed a dominant antihypertensive effect in the normotensive and I-degree hypertensive patients compared to the placebo group.

evidence

~Safety~

Non-clinical trial

◆ Single oral toxicity test ⁴⁾

◆ 90-day repeated oral toxicity test ⁵⁾

◆ Chromosome aberration test ⁶⁾

◆ Reverse mutation test ⁷⁾

Human clinical trials

◆Overdose test (3 times the amount Test period 1 month)⁸⁾

◆ Continuous intake and overdose for normotensives
(Normal dose and triple dose Test period 3 months)⁹⁾⁹⁾

1) Biosci. Biotechnol. Biochem., 68 (4), 767–773, 2004
2) J Eur Acad Dematol Venereol 2013 27(10): 1269-77
3) Food Chemistry 113 (2009) 238–245
4) Single oral dose toxicity test of royal jelly degradation product in rats (internal report)
5) 90-day oral toxicity test using royal jelly degradation product in rats (internal report)
6) Reverse mutation test using royal jelly degradation products using bacteria (internal report)
7) Chromosome aberration test using cultured mammalian cells of royal jelly degradation product (in-house report)
8) For people with normal high blood pressure and mild hypertension of drinks containing royal jelly decomposition products
Efficacy and safety, Shuji Kajimoto et al., The Japan Society of Health Sciences.
21(2):229-245(2005)
9) Continuous ingestion and overdose of royal jelly hydrolyzate-containing beverages for normotensive persons
Safety, Shuji Kajimoto et al., New drug and clinical review. 54(5):110-127(2005).

Efforts toward Foods with FunctionClaims Peptides derived from royal jelly: 320mg/day
Royal jelly-derived 10-hydroxy-2-decenoic acid: 35 mg/day

royal jelly 3000

Notification number: E609

Product name: Royal Jelly 3000

Functional component name:

This product contains royal jelly-derived peptides and royal jelly-derived 10-hydroxy-2-decenoic acid. Peptides derived from royal jelly and 10-hydroxy-2-decenoic acid derived from royal jellyhave been reported to have the ability to prevent moisture from escaping from the skin.

Foods with function claims re-notification system
Yes!

Raw royal jelly

In addition to proteins, sugars and lipids, each vitamin and mineral
Includes a good balance.

Property
Light yellow cream.

Deproteinized Royal Jelly Extract

A clear white extract of royal jelly extracted with ethanol.
It can be used for soft drinks, jelly, etc.

Property
Pale yellow transparent liquid

Dried royal jelly

A vacuum lyophilized powder of raw royal jelly.
One gram of dry royal jelly powder is equivalent to 3 g of raw royal jelly.

Property
Pale yellow powder

Deproteinized Royal Jelly Powder